E,Z-Stereodivergent synthesis of N-tosyl α,β-dehydroamino esters via a Mukaiyama–Michael addition
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منابع مشابه
Stereodivergent Olefination of Enantioenriched Boronic Esters
A stereodivergent coupling reaction between vinyl halides and boronic esters is described. This coupling process proceeds without a transition-metal catalyst, instead proceeding by electrophilic selenation or iodination of a vinyl boronate complex followed by stereospecific syn or anti elimination. Chiral, nonracemic boronic esters could be coupled with complete enantiospecificity. The process ...
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Tosyl esters of Indole acetic acid and Naphthalene acetic acid were prepared by treating the acids with ptoluenesulfonyl chloride in the presence of a strong base triethylamine. The synthesized compounds were identified by TLC technique. IR and 1 H-NMR spectral measurements were carried out to characterize and elucidate the structure of the synthesized compounds. Anti microbial activity on the ...
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A stereodivergent asymmetric Lewis base catalyzed Michael addition/lactonization of enone acids into substituted dihydrobenzofuran and tetrahydrofuran derivatives is reported. Commercially available (S)-(-)-tetramisole hydrochloride gives products with high syn diastereoselectivity in excellent enantioselectivity (up to 99:1 d.r.syn/anti , 99 % eesyn ), whereas using a cinchona alkaloid derived...
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Fatty acyl esters of N-hydroxysuccinimide have been used to directly N-acylate sphingenine or sphinganine, forming the corresponding ceramides. The reaction proceeds in excellent yield (84-96%) from small amounts of starting material (10-20 mg). The product ceramides are pure after one recrystallization.
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2016
ISSN: 2046-2069
DOI: 10.1039/c5ra27354d